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Exploratory endpoints reported herein include change from baseline to week 104 in glycemic category, antihypertensive medication use and lipid-lowering medication use

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According to a peer-reviewed study published in PLOS ONE confirming that Semax affects the expression of genes related to the neurotrophin signaling pathway, specifically upregulating BDNF in the hippocampus, Semax significantly increases BDNF and its receptor TrkB in the rat hippocampus, with effects on both memory and neuronal resilience

Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense