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Each of these findings is cited verbatim in the warning letter, underscoring how an unvalidated change, an incomplete investigation, or a missing SOP attachment can render an entire quality system suspect

Clinical samples and model studies further validate the clinical significance of the ACSL4LPCAT3 axis: in drug-resistant tumor tissues from patients with triple-negative breast cancer, ACSL4 expression levels were 2.8-fold higher than in sensitive tumors, and patients with high ACSL4 expression exhibited significantly enhanced responses to ferroptosis inducers combined with chemotherapy (37);In clear cell renal carcinoma cells, LPCAT3 expression is positively correlated with the levels of PE-AA and PE-AdA

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Given PCs importance in cellular metabolism, its activity is tightly regulated