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Moreover, it is essential to investigate combination therapy, such as curcumin in conjunction with conventional treatments, and to conduct mechanistic research to elucidate pathways like Nrf-2 or PPAR-LXR-ABCA1

Common symptoms include: Weight loss or failure to gain (especially in puppies) Chronic diarrhoea or soft stools Lethargy and general weakness Inappetence or fussy eating Intermittent vomiting Flatulence or digestive discomfort Poor coat condition or dull fur Neurological signs (e.g., tremors, confusion, ataxia) Low folate or folate imbalance on bloodwork In puppies or young dogs with genetic B12 absorption issues, growth may be stunted , and immune function may be compromised

It is worth noting that three out of the four products generated by transketolase, namely, two molecules of glyceraldehyde 3-phosphate and one of fructose 6-phosphate, are also key intermediates of glycolysis

[DOI] [PubMed] [Google Scholar] 32.Meyer AJ, et al