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Since the publication of this systematic review, another study reported no difference in the prevalence of diabetic neuropathy in patients with screen-detected T2DM who received routine care compared with those who received intensive treatment (encompassing goal-directed glycaemia and cholesterol and blood-pressure management) 163

Direct correlations between Alox15 polymorphisms and biochemical measurements of oxidized lipoproteins or oxPL and oxidized cholesterol esters have not been reported to date in humans, but are clearly needed

Effects of Ido1 activity include promotion of T cell- mediated tolerance and antimicrobial effects 154 and Ido1 might also act at the site of expression to decrease T-cell proliferation and survival, diminishing colonic inflammation and reducing disease severity 155
