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By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance ( IDO1 plays a key role in immune escape in AML, but targeted therapy is still in the early stage of exploration

We explored the crosstalk between these networks to identify key alterations in metabolic regulation

The results revealed that Michael had high levels of mercury in his system and a severe sensitivity to gluten, both of which were fueling his inflammation

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