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Cette injection est principalement recommande pour les patients incapables de prendre des mdicaments oraux, comme avant ou aprs une chirurgie

Furthermore, even removing p53 from the equation by knocking it down had not revoked the MIRA-1-induced apoptosis, which indicated an additional p53 -independent apoptotic pathway mediated by MIRA-1 [708]

A strength of this work was that these findings were then validated by shRNA knockdown of IRP2 and its negative regulatory E3 ubiquitin ligase FBXL5, which resulted in reduced and enhanced sensitivity to ferroptosis induction, respectively

[DOI] [PMC free article] [PubMed] [Google Scholar] Schapira AHV, Chaudhuri KR, Jenner P