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Description
This study reports the crystal structure of the BTB domain of KEAP1 in complex with a cyanoenone triterpenoid

In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

HSCs cooperate with innate immune cell populations to initiate hepatic inflammation during the transition from simple steatosis to steatohepatitis

[DOI] [PubMed] 10.Schalka S, dos Reis VM, Cuce LC
