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Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial

You may experience some mild tenderness, redness and swelling around the injection site

For references and more information , see the section on high homocysteine in the Choline article
Higher doses do not necessarily produce better results and may increase the risk of side effects like headaches or gastrointestinal discomfort without improving fat loss outcomes
