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Biomed Res Int 2014, 482704.CrossRefGoogle ScholarPubMed

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Reconstructing double-stranded DNA fragments on a single-molecule degree reveals patterns of degradation in historic samples Intensive manipulations concerned within the preparation of DNA samples for sequencing have hitherto made it unimaginable to find out the exact construction of double-stranded DNA fragments being sequenced, such because the presence of blunt ends, single-stranded overhangs, or single-strand breaks