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Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8(+) T cells and exhibit a distinct CD95(hi) B cell phenotype
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In rheumatoid arthritis models, probiotic-induced DCA/LCA activated TGR5 (likely Gs-cAMP mediated given the anti-inflammatory outcome) to suppress Th1/Th17 responses, an effect nullified by the TGR5 antagonist SBI-115 (79)
