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When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Estrela JM, Gil F, Vila JM, Vina J

Role of nuclear glutathione as a key regulator of cell proliferation

Daily use for 12 weeks reportedly gives better results than sporadic use for 6 months