glutathione can cause high blood pressure deficiency and heart failure: a systematic review of human and animal evidence Glutathione metabolism and glutathione-dependent cellular
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From this point of view, targeting new AD drugs to increase mitochondrial bioenergetics by regulating mitochondrial biogenesis or CoQ 10 biosynthesis in the brain appears to be a more appropriate pharmacological strategy

This typically resolves within the first few days as the body adjusts

doi: 10.1111/j.1530-0277.1995.tb01560.x
