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It may thus be suggested that direct exposure of the gut to the microbiome - capable of synthesizing thiamine antagonists or possessing thiamine-degrading thiaminase II - may first of all affect the gut, leading to gastrointestinal beriberi, especially under conditions of SIBO or other disturbances of the gut microbiome

[DOI] [PMC free article] [PubMed] [Google Scholar] 261.Van de Velde LA, Subramanian C, Smith AM, Barron L, Qualls JE, Neale G, Alfonso-Pecchio A, Jackowski S, Rock CO, Wynn TA, and Murray PJ (2017)

In 1990, Pitt was the first to describe how chronic paracetamol ingestion leads to accumulation of pyroglutamic acid/5-oxyproline

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