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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104
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The SULT genes help with phase II detoxification of estrogens, neurotransmitters, certain carcinogens, and steroid hormones
