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In fact, at the end of treatment, the tumor volume of the control group (animals treated with PBS or BSO alone) was increased by ~35-fold in relation to that on the first day of treatment, whereas, in the group treated with the three drugs together, the average tumor volume was about the same as that at the beginning of treatment (Figures 6b, c and e)

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In our study, we observed that isolated treatment with TMZ reduced TXNRD1 expression, while co-exposure with DPDS potentiated this effect (Fig