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Concurrently, EPA and DHA serve as precursors to specialised pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, which bind formyl peptide receptor 2 (FPR2)/lipoxin A4 receptor (ALX) and G protein-coupled receptor 120 (GPR120) to promote M2 macrophage (M2) polarisation, accelerate efferocytosis, and resolve inflammation [253,254]

Giniatullinn RA et al (2000): Rapid Relief of Block by Mecamylamine of Neuronal Nicotinic Acetylcholine Receptors of Rat Chromaffin Cells In Vitro: An Electrophysiological and Modeling Study

A holistic approach is required, beyond traditionally predominant pharmacological interventions, and needs consideration of mechanistically driven nonpharmacological interventions

HormoneSynergy patients should use supplements as directed by their care team