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In general, by either excess or impairment, NO appears to cause or contribute to a variety of disturbances, in particular, hypertension, angina, impotence, circulatory shock, septic shock, stroke, inflammation, respiratory distress syndromes, pulmonary hypertension, adhesion and aggregation of platelets and leukocytes, diabetes, hypotension, and Parkinson's disease
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When glutathione is depleted, these detoxification pathways become impaired, leading to toxic buildup that can worsen liver damage

Patients with bilateral vestibulopathy have an unsteady wide-based gait and a tendency to fall to either side
