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Concurrently, it plays a pivotal role in essential processes such as DNA synthesis, bolstering the bodys defense against oxidative stress, maintaining endoplasmic reticulum integrity, synthesizing thyroid hormones, and regulating gene expression of transcription factors, including (NF-B), apurinic/apyrimidinic endonuclease/redox factor-1 (Ref-1), activator protein-1 (AP-1), apoptosis-regulating kinase (ASK1), and glucocorticoid receptor 65

Q., Wohlschlegel, J., Dillin, A

ChREBP mediates carbohydrate, but not fat-induced DNL as high fat diets do not activate ChREBP and may even decrease ChREBP activity [43, 47]

10.1042/bj2220371 173 RoweS