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Gut dysbiosis and disrupted intestinal barrier function could worsen pulmonary symptoms, augment neurological or hepatic inflammation through translocation of endotoxins and bacteria via portal veins 239,240,241

Role of HrpA in biofilm formation of Neisseria meningitidis and regulation of the hrpBAS transcripts

Although anti-cancer therapy targeting metabolism has achieved some gratifying results, it is still currently believed that this field has the following shortcomings for possible future breakthroughs: 1) The side effects of such drugs limit their clinical effects as the optimal dose window is hard to be determined

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