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Anthony Didato, DMD Balanced Aesthetics + Wellness 90% of Serotonin Produced in the Gut Approximately 90% of the body's serotonin the neurotransmitter most associated with mood regulation is produced by enterochromaffin cells Cell (Yano et al., 2015) Gut-Brain Axis Bidirectional Communication The gut-brain axis describes bidirectional signaling between the enteric nervous system and central nervous system via the vagus nerve, immune Annals of Gastroenterology Leaky Gut (Intestinal Permeability) and Systemic Inflammation Increased intestinal permeability allows endotoxins (LPS) to enter the bloodstream, triggering systemic inflammatory cascades linked to anxiety, depression, brain fog, Frontiers in Immunology Overnight Fasting Improves Microbial Balance A 12-14 hour overnight fast improves microbial balance and insulin sensitivity

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Vukojevic J., Siroglavic M., Kasnik K., Kralj T., Stancic D., Kokot A., Kolaric D., Drmic D., Sever A.Z., Barisic I., et al

161 More research is needed to better understand the mechanisms that link social and cognitive engagement to dementia risk, along with types of activities that provide benefit and how often they should take place