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For instance, those allergic to cobalt or with Leber's disease should avoid vitamin B12 injections

In cases of long-standing or severe deficiency, nerve damage may be partially irreversible, highlighting the importance of early detection and treatment

In 1992, the General Accounting Office (GAO)the historical predecessor to the Government Accountability Officereleased the report Womens Health: FDA Needs to Ensure More Study of Gender Differences in Prescription Drug Testing, ushering a new era of focus on the issue of diversity in clinical trials