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As with any medication, side effects are possible

Sci Rep 2021;11:1940

Vitamin B12 and Nerve Damage Caused by Nitrous Oxide/Laughing Gas Nerve damage caused by B12 deficiency can also be triggered by the use of the nitrous oxide, which is frequently used by dentists

alternate supplement formulations of vitamin B 12 , such as methylcobalamin and hydroxycobalamin, have been suggested for this patient population
