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After LPL hydrolyzes TRLs, sortilin, a member of the vacuolar protein sorting 10 (or VPS10) family, facilitates the uptake of secreted LPL and transfers it to endosomes in parenchymal cells, and LPL ends up in lysosomes for degradation [50,84]

and (iii) translocation of the toxin into the cytosol and ADP-ribosylation of actin and microtubule protrusion formation (Figure 6)

This metabolic activity is crucial particularly for organs like the heart and muscles which are in constant need of energy