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The overexpression of IDO, both in uninfected antigen-presenting cellsinduced by IFN-, TNF-, and IL-6 or by activation of RIG-I/TLR3 by EBERs or by activation of TLR2 by EBV dUTPaseas well as in EBV-transformed antigen-presenting cellsinduced by TNF- and IL-6 via MAPK/p38 and NF-Bsuppresses the activation and proliferation of antiviral T cells (CD4 and CD8) and decreases the cytotoxic activity of CD8 T cells by binding kynurenine catabolites released by antigen-presenting cells to the aryl hydrocarbon receptor (AhR) [10, 202, 320, 322, 323]

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The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism

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