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Science 362, 14161422

A finding has indicated that hyperphosphorylation of cAMP-responsive element-binding protein and reduced expression of brain-derived neurotrophic factor in the cerebral cortex might be involved in high levels of anxiety-like behavior in dexamethasone-treated rats [138]

In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks