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While adrenal fatigue is not officially recognized in conventional medicine, functional medicine practitioners may use saliva or blood tests to measure cortisol levels throughout the day

SOS is the most typical histological change, and is characterized by impaired sinusoidal wall integrity, sinusoidal hyperemia and blockage, sinusoidal fibrosis, fibroid blockage in the lobular central vein and nodular hyperplasia or hemacelinosis (18)

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