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DAMPs such as HMGB1 and S100A8/A9 secreted by adipocytes bind to RAGE, promoting macrophage polarization toward the M1 phenotype and releasing proinflammatory cytokines, thereby exacerbating systemic low-grade inflammation 56,163
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Darkening of moles is the one side effect of melanotan II an individual would want to keep a close eye on. TMR approached the company for comment but has not received a response
Varbo A, Nordestgaard BG
