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Pycnogenol : In a study in psoriasis patients, the addition of pycnogenol to standard treatment resulted in significant improvement in skin redness, hardening, and scaling compared with standard treatment alone

When endothelial NOS function is abnormal caused by pathological stimulating factors such as insulin resistance, impaired glucose tolerance and obesity, its catalytic process becomes "uncoupled," leading to the production of superoxide anion (O) instead of NO

Early recovery from hypoxic pulmonary hypertension: a structural and functional study

References Aeberhard EE, Henderson SA, Arabolos NS, Griscavage JM, Castro FE, Barrett CT, Ignarro LJ (1995) Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene