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J Biochem Biophys Methods 13 : 231249 Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, Anderson ME (1992) High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis
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This substitution results in an alanine-to-valine change, leading to a significant reduction in the enzyme activity observed in vitro in both heterozygotes and homozygotes [67,108]
