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This complex cleaves pro-IL-1 via caspase-1 to generate active IL-1 (a key inflammatory mediator), concurrently inducing gasdermin D-mediated pyroptosis

Breast cancer Initial studies of breast cancer risk associated with GPx-1 Pro198Leu polymorphisms reported a higher frequency of the Leu/Leu genotype in breast cancer tissues from African American women than the Pro/Pro genotype compared to the distribution of these genotypes in normal cancer free individuals (175)

Furthermore, a preclinical study demonstrated that circulating MPs may impair brain function via immune-mediated vascular occlusion (Huang et al., 2025)

doi: 10.1016/s0014-2999(99)00200-9