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The damaging effects of Nrf2 modification in the lung, as an example, may increase the susceptibility of the affected tissues to the oxidative stress of the oxygen environment, as well as compromise the function of epithelial cells and phagocytes, such as granulocytic leukocytes and monocytes/macrophages [49,50]

Research studies funded by WADA, as referenced in the Explanatory Note have also confirmed the potential for tramadol to enhance sports performance

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[DOI] [PubMed] [Google Scholar] 2.Schrama D., Reisfeld R.A., Becker J.C