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17 The diagnosis of electrocardiogram and chest radiograph were reviewed and evaluated by the corresponding author (Dr

ELA is defined as exposure to adverse experiences during the first years of life, including adverse childhood experiences (ACEs) such as exposure to war or natural disasters, physical or sexual abuse, malnutrition, parental psychopathology, and adverse parental behaviors such as abuse, neglect, distant parent-child relationships, and unpredictable or disorganized parental care[36,40]

Further studies revealed that DSF/Cu caused mitochondrial and nuclear DNA damage and the release of cytosolic dsDNA by inducing excessive reactive oxygen species (ROS) generation, thereby triggering innate immunity and enhancing anti-tumor effects