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If supplementation is responsible, your doctor may recommend reducing or stopping non-essential B12 intake, with repeat testing after an appropriate interval (typically 2-3 months, or longer if you've had recent injections or have kidney disease)

In light of these data, we suggest therapies that target energy metabolism and ROS generation to improve kidney function recovery may need to also target the energy and redox derangements observed in the liver

This is why both therapies are often discussed in longevity and performance circles, not as competitors, but as complementary tools

This is research-significant because NAD+ is essential for sirtuin function, PARP-mediated DNA repair, and mitochondrial metabolic pathways, all processes that deteriorate in aging biology