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So, based on a balanced view of the current research, if you wish to take adenosylcobalamin or methylcobalamin (or better, a mixture of the two!) we recommend aiming to get between 400mcg to 500mcg daily if you are under 65 years old

Chronic conditions (tendonitis, joint issues): Typically requires 48 weeks of consistent use to see substantial improvements, with continued benefits over 12+ weeks

Tasks become easier, focus sharpens, and motivation increases

Moreover, the meta-analysis of Boushey et al (1995) indicates that a daily folate supplement at doses as low as 400 g may induce a 6 mol/L decrease in plasma homocysteine and prevent 28,000 deaths per year by myocardial infarction