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DOI: 10.1016/S0736-4679(00)00259-2 Gillman K (2017a): Much ado about nothing: monoamine oxidase inhibitors, drug interactions, and dietary tyramine

In addition, BDMC suppresses breast cancer (BT-549, MDA-MB-231, and MCF-7) progression through down-regulating cancer metastasis-related proteins (MMP-9 and TWIST1) and inducing pro-apoptotic proteins (p53) expression [404, 405]

These alterations may be further exacerbated by oxidative stress and activation of profibrotic cytokines, such as transforming growth factor , ultimately contributing to the development of chronic kidney disease (82)

Superoxide anion radicals (O2 ) can cause injury directly and can be converted into more damaging oxidant species such as hydroxyl radical (OH ) and hypochlorous acid (HOCl).37 Of the two, OH has been demonstrated as the key reactive oxygen species to cause pulmonary edema during acute lung injury.38 Hypoxemia secondary to Adult Respiratory Distress Syndrome (ARDS) and pulmonary edema may occur during COVID-19 infection.39 Besides causing tissue injury, ROS can also activate the NF-kB pathway to amplify inflammation through upregulation of expression of multiple genes, such as IL-6, TNF-, and chemokines