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Nature Neuroscience 6: 267273
Patients with GBM have median survival of less than 1 year while those affected with grade II astrocytomas could live for 10 to 15 years [384]
doi: 10.3390/v12010066 59 Otulak-KozieK.KozieE.PrzewodowskiW.CiackaK.PrzewodowskaA
Moreover, it caused nuclear p53 exclusion and induced apoptosis selectively in senescent Leydig cells by disrupting the FOXO4-p53 interaction, which may be a critical mechanism underlying its therapeutic effect
