methylglyoxal glutathione The glyoxalase system. first binds with glutathione, N5,N10‐methylenetetrahydromethanopterin reductase from Methanocaldococcus jannaschii

doi: 10.1093/jnci/89.23.1789

The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway

It is our hypothesis that in the setting of COVID-19 and oxidative stress, patients with comorbidities may have compromised levels of GS and GCL, the enzymes involved in GSH synthesis For this reason, we suggest directly supplementing liposomal glutathione, instead of NAC as patients with deficient levels of GS and GCL will not be able to use NAC as substrate for GSH synthesis

Research Concentration: In murine models, daily research dosages typically range from 20mg/kg to 30mg/kg of body weight to assess metabolic shifts over a 46 week cycle