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Key challengessuch as optimizing peptide design, ensuring biosafety, refining delivery systems, and improving preclinical modelsare critically analyzed

This effect was also seen in the striatum of HIV-infected, encephalitic brains (Meulendyke et al., 2014) and suggests that accelerated dopamine breakdown could produce ROS to increase myeloid cell activation and drive neuroinflammation

ROS initiate lipid peroxidation, alter protein structure, enhance the release of arachidonic acid from cell membranes, increase the synthesis and release of chemoattractants, and induce the release of tachykinins and neurokinins 14,15
