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All of these therapies have shown a rapid onset of action and benefits to patients not doing well on other therapies

These findings collectively demonstrate that EC metabolism involves a coordinated sequence of intestinal absorption, hepatic and colonic biotransformation, and renal elimination, with distinct phase II conjugates acting as clearance intermediates and serving as characteristic metabolic signatures of EC exposure (Figure 3)

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Therapeutic implications Based on the role of ROS in breast cancer, several reagents have been reported to be potential therapeutic methods for patients with breast cancer