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281,282,283 In the TME, Gln metabolic reprogramming is essential for the survival of tumor cells and immune cells, and there is competition for Gln uptake
In the long term, it leads to a decrease in GH secretion, probably reducing GHRH sensitivity (381)
FOXO4 knockdown resulted in increased levels of p53 and Ser15-phospho-p53, but paradoxically decreased the level of p21
A common water-soluble molecule called glutathione (GSH) is present in many tissues and cells at millimolar concentrations [3]
