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No published study has demonstrated this, but the question remains open (Crockford et al., Ann N Y Acad Sci 2010)

[DOI] [PMC free article] [PubMed] [Google Scholar] 192.Sydor A.M., Jost M., Ryan K.S., Turo K.E., Douglas C.D., Drennan C.L., Zamble D.B
10.1186/s12964-021-00733-y [DOI] [PMC free article] [PubMed] [Google Scholar] 316.Cho, Y.-H

Folate supplementation may not achieve the expected effectiveness, in part because of feedback mechanisms within the methionine cycle
