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Golovine K, Makhov P, Naito S, Raiyani H, Tomaszewski J, Mehrazin R, et al

Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

Metformin is the go-to oral antidiabetic drug for Type 2 Diabetes
Acta Oncol (2015) 54(9):132634
