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The consistency of positive outcomes across multiple studies, combined with the excellent safety profile, provides a strong foundation for considering this regenerative approach

Importantly, prolonged overnutrition can increase the progression of NAFLD to NASH with fibrosis [20, 21]

Antiviral activity of phenformin in vivo Given that phenformin is an established drug in humans with known pharmacokinetics and safety profiles, that is hence readily available, we further evaluated the in vivo antiviral potential of phenformin against SARS-CoV-2 in a Golden Syrian hamster model of infection (Fig