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GSNO plays a key role in nitric oxide-mediated cellular signaling and can regulate protein function through a process called S-nitrosylation
The presence of HO-1 significantly reduces the levels of inflammatory markers associated with diabetic wounds such as TNF-, IL-1, IL-6, iNOS, COX2, MCP-11, and MIP-1, while simultaneously boosting the levels of IL-10 [126]
This conjugate is not excreted as such in the urine but undergoes cleavage, first by the enzyme -glutamyl transpeptidase to release the free glutamyl residue and cysteinyl glycine derivative
