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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern
High-dose cyanocobalamin leads to accumulation of cyanide in patients with renal failure
Hasday JD, Thompson C, Singh IS
Laughlin GA, Barrett-Connor E, Bergstrom J
