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Indeed, 1 mM APAP-CYS induced a significant glutathione reduction only after 4 h of incubation

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While the exact immunopathogenesis of DILI is still unclear, its mechanisms may involve direct toxic effects, metabolic disturbances, and both metabolic and allergic idiosyncrasies

Of these, 13% occurred during pregnancy, 18% occurred within 42 days of the end of pregnancy, and 69% occurred between 43 days and one year after the end of the pregnancy