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J Pharmacol Exp Ther (2012) 344:14154.10.1124/jpet.112.199497 137 CollierTJKiptonJDaleyFPalfiSChuYSortwellCet alAging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism

According to a 2017 systematic review in the Journal of Clinical Nursing confirming that aspiration before subcutaneous injection does not reduce adverse events, subcutaneous injections carry a distinct pharmacokinetic profile that intramuscular delivery disrupts, which is why correct angle and depth matter for predictable results

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