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Patients with low-normal or borderline B12 (200400 pg/mL) may experience quicker symptom relief and fewer adverse effects than those with truly deficient levels, who may require supplemental or prescription-grade B12 dosing instead

There are no completed Phase 2 or Phase 3 clinical trials of 5-Amino-1MQ in human participants, and no NNMT inhibitor has reached regulatory approval for any indication

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