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It is studied for CNS-mediated mechanisms acting on melanocortin receptors (MC3-R and MC4-R) in the brain rather than through peripheral vascular pathways
Our finding is in agreement with a prospective study reporting that baseline TMAO positively associated with rates of eGFR decline 21 and with studies in animal models of CKD where TMAO diet supplementation increased kidney injury 44,45 and reduced eGFR
A fishy odor to the breath, sweat and urine has been reported
