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Authors Contributions All authors were involved in the data interpretation, writing and reviewing drafts of the manuscript and approved the final version for submission

A 2019 review found that not only does testosterone appear to activate the serotonin system, but it also increases the neuroplasticity of the brain

KPV is attractive to researchers because it seems to target important inflammatory pathways without producing the broad immune suppression observed with many drugs

In macrophages, mtDNA also contributes to NLRP3 and AIM2 inflammasome activation, which leads to the activation of caspase-1 and subsequently the maturation of pro-IL-1 and pro-IL-18 (149, 150)